Biography
Education
- Submitted Ph.D thesis titled Computer Assisted Design, Synthesis and Biological Evaluation of Some Novel Heterocyclic Compounds to The Tamilnadu Dr. M.G.R Medical University, Chennai, Tamilnadu [December 2009].
- PGDB (Post Graduate Diploma in Bioinformatics) - St Josephs Academy of Information Technology, Bangalore, 2006-2007- with distinction.
- M. Pharm (Master of Pharmacy-Pharmaceutical Chemistry), Rajiv Gandhi University of Health Sciences, Bangalore, 2001-2003 - with First Class
- B. Pharm (Bachelor of Pharmacy), Bapuji College of Pharmacy, Kuvempu University, BR Projects, Shimoga, 1993-1997.
- D. Pharm (Diploma in Pharmacy), BES School of Pharmacy, Board of Examination for Diploma, Bangalore 1992-1993
Work History
Present position
- Asst.Professor, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ooty, Tamilnadu, India. April 2004-till date.
Other Positions Held
- Visiting faculty for St Josephs Academy of Information Technology, Residency Road, Bangalore for about five years to teach Pharmaceogenomics and to PGDB students. January 2003-2007.
- Lecturer at KLE College of Pharmacy, Rajaji Nagar, Bangalore for one year, March 2003-2004
- Quality Assurance Chemist at Remidex Pharma Pvt Ltd., Bangalore for about 3 years, Was part of - In process inspection, Validation, QC inspection and Documentation team. 1998 to 2001
Research Interests
- Working in the field of "Medicinal Chemistry".Specially, on CADD techniques, organic/heterocyclic synthesis, analysis and biological evaluation of new molecules for various targets such as diabetes, cancer, HIV and tuberculosis.
- Currently, we are developing of newer and safer glitazones as insulin sensitizers
Publications ( total number of publications)
Published 22 research articles in various national and international journals,
- B. R. Prashantha Kumar, M. J. Nanjan. Novel glitazones: Design, synthesis, glucose uptake and structure-activity relationships. Bioorganic & Medicinal Chemistry Letters 20, 1953 (2010).
- B.R. Prashantha Kumar, Gopu Sankar, R.B. Nasir Baig and Srinivasan Chandrashekaran, Novel Biginelli dihydropyrimidines with potential anticancer activity: A parallel synthesis and CoMSIA study, European Journal of Medicinal Chemistry 44, 4192 (2009).
- B.R. Prashantha Kumar and M. J. Nanjan. Comparative molecular similarity indices analysis for predicting the antihyperglycemic activity of thioglitazones, Medicinal Chemistry Research 18 [DOI 10.1007/s00044-009-9246-0] (2009).
- B. R. Prashantha Kumar, Mukesh Soni , U. Bharvi Bhikhalal, Ismayil R. Kakkot, Meghana Jagadeesh, Praveen Bommu and M. J. Nanjan, Analysis of physicochemical properties for drugs from nature, Medicinal Chemistry Research 18 [DOI 10.1007/s00044-009-9244-2] (2009).
- B. R. Prashantha Kumar, Pankaj Masih, E. Karthikeyan, Ankur Bansal, Suja. Pottekad Vijayan. Synthesis of novel Hantzsch dihydropyridines and Biginelli dihydropyrimidines of biological interest: a 3D-QSAR study on their cytotoxicity. Medicinal Chemistry Research 18 [DOI 10.1007/s00044-009-9195-7] (2009).
- B. R. Prashantha Kumar, Pankaj Masih, Chris Raju Lukose, Nimmy Abraham, D. Priya, Rinu Mary Xavier, Kesiya Saji, and Laxmi Adhikary. Facile. Microwave-Assisted Parallel Syntheses of N-Substituted 1,4-Dihydropyridines of Biological Interest. Journal of Heterocyclic Chemistry 46, 336 (2009).
- B. R. Prashantha Kumar, Gyanendra Kumar Sharma, S. Srinath, Mohamed Noor, B. Suresh, and B. R. Srinivasa. Microwave-Assisted, Solvent-Free, Parallel Syntheses and Elucidation of Reaction Mechanism for the Formation of Some Novel Tetraaryl Imidazoles of Biological Interest, Journal of Heterocyclic Chemistry 46, 278 (2009).
- Prashantha Kumar B. R, M. D. Karvekar, L. Adhikary, M. J. Nanjan and B. Suresh. Microwave assisted syntheses of thiazolidine-2,4-dione motif and microwave induced efficient synthesis of 5-Benzylidene-thiazolidine-2,4-dione and 5-Benzylidine-2-thioxo-thiazolidine-4-one compounds, Journal of Heterocyclic Chemistry 43, 897 (2006).
- B. R. Prashantha Kumar, T.K. Praveen, M.J. Nanjan, M.D. Karvekar, B. Suresh. Serum glucose and triglyceride lowering activity of some novel glitazones against dexamethasone induced hyperlipidemia and insulin resistance. Indian Journal of Pharmacology 39(6), 299 (2007).
- Prashantha Kumar B R, Yuvaraj S, Gyanendra kumar Sharma, M J Nanjan and B Suresh. Syntheses, CoMFA study and biological evaluation of 1,4-dihydropyridines. Letters in Drug Design & Discovery 5 (1), 7 (2008).
- B. R. Prashantha Kumar, Bijoy J. Desai, J. Vergheese, Praveen TK, B. Suresh and M. J. Nanjan, CoMFA Study on Thiazolidine-2,4-dione Derivatives for their Antihyperglycemic Activity. Letters in Drug Design & Discovery 5(3), 79 (2008).
- B. R. Prashantha Kumar and M. J. Nanjan, QSAR Study on Thiazolidine-2,4-dione Derivatives for their Antihyperglycemic Activity. Indian Journal of Pharmaceutical Sciences 70 (5): 565 (2008).
- Prashantha Kumar B. R, "Drug Price in India after GATT implementation" www.pharmainfo.net, Canada, 2005 (Article won the second prize out of 124 contestants from all over India).
- V. Ravichandran, B.R. Prashantha Kumar , S. Sankar and R.K. Agrawal,Predicting anti-HIV activity of 1,3,4-thiazolidinone derivatives: 3D-QSAR approach, European Journal of Medicinal Chemistry 44, 1180 (2009).
- Veerasamy Ravichandran, B. R. Prashantha Kumar, Sundaram Sankar and Ram Kishore Agrawal, Comparative molecular similarity indices analysis forpredicting anti-HIV activity of phenyl ethyl thiourea (PET) derivatives, Medicinal Chemistry Research 17, 1 (2008).
- Three papers are in pipe line
Major Achievements
- (Patent: Filed an Indian patent titled "Thiazolidinediones and their process thereof" under the institution name through TIFAC (Published in the official gazette of Indian governmnet-2006-07, No.648/CHE/2006).
- "Award Citation" from Govt College of Pharmacy, Bangalore, for securing highest marks during M. Pharm studies.
- Qualified in "GATE-2000 Pharmaceutical Sciences".
- Developed PTSA as an efficient catalyst for synthesizing some novel Biginelli dihydropyrimidines.
- Elucidated reaction mechanism for three organic reactions and are published in Journal of Heterocyclic Chemistry.
- Filed a patent titled "Thiazolidinediones and process thereof.." in the year 2006.
- Some of my students are perusing their masters at some of the prestigious universities in USA and Australia.
Date: 30-08-2010
Prashantha Kumar BR
Place: Ootacamund
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