Pharmaceutical Chemistry

Aimed to deliver expertise in the emerging areas of Drug Discovery, Drug Design, Develop documentation/research writing expertise. The department is also committed to deliver skills in the innovative processes for the manufacturing of drug and drug intermediates and their quality assurance using sophisticated instruments.

Objective

  • Hit to Lead and Lead Optimization
  • Innovative process development for the synthesis Drugs and Drug Intermediates
  • API handling
  • Patent and Regulatory Affairs

Research and Teaching

  • Teaching at B. Pharm, M. Pharm and Pharm. D courses
  • Full time research leading to Ph. D
  • Collaborative research
  • Sponsored research projects from various funding agencies like, DST, DBT, UGC, AICTE, CSIR, ICMR, etc.

Thrust Area of research

  • In silico drug design and development of novel chemotherapeutic agents
  • Custom synthesis  based on  various biological targets
  • Design and synthesis of novel compounds for anti-inflammatory and neurobehavioural activities
  • Polymeric Drug design
  • Isolation, characterization and evaluation of bioactive constituents from natural sources

Faculty

Sl.No. Name of the Faculty Qualification Designation
1 Dr. Md. Afzal Azam M. Pharm. Ph. D. Head
2 Dr. S. Sankar M. Pharm. Ph. D. Professor
3 Dr. M. J. N. Chandrasekar M. Sc.  Ph. D. Professor
4 Mr. R. Kalirajan M. Pharm. Assistant Professor
5 Mrs. S. Jubie M. Pharm. Assistant Professor
6 Mrs. B. Gowramma M. Pharm, Ph.D. Assistant Professor
7 Mrs. S. Gomathy M. Pharm. Lecturer

Supporting Staff : 06

Sl. No.   Name of the Staff Qualification Designation
1 Mr. V. Mahadevaswamy B.Sc. M. A. Lab.Technician
2 Mr. D. Lingarajamurthy S .S. L .C Lab.Assistant
3 Mr. A. Venkatesh S. S. L. C Lab.Assistant
4 Mr. S.R.Ramachandra P.U.C Lab.Assistant
6 Mr. S. Shivakumar B.Com Lab.Assistant

Research projects from various funding agencies: Research Grants received

Sl. No Name of the Project Funding Agency Period Amount
(Lakhs)
1. Design, synthesis and evaluation of some novel dipeptidyl peptidase IV inhibitors as antidiabetic agents. In collaboration with JSSCP, Mysore) UGC, Government of India, New Delhi. 2011-2014 10.86 Lakhs
2 Synthesis characterization and evaluation of their cytotoxic and antimicrobial activities of some novel heterocyclic compounds. RPS, AICTE , Government of India, New Delhi 2011-2013  
14.0 Lakhs
                                                                                                                                       Total 24.86 Lakhs

Projects Completed (2008-2013)

Sl. No Name of the Project Funding Agency Period Amount
(Lakhs)
1. Isolation, Screening & Characterization of the Fertility Regulating phyto-constituents present in the Traditional plants of the Nilgiris, Derris brevipes, Durio zibenthinus. CSIR,
Government of , 
India, New Delhi.
2009-12 11.80 Lakhs
2. Targeting anticancer macromolecular prodrugs. DST,
Government of India, New Delhi..
2006-09  
 6.26 Lakhs
3 Computer aided design, synthesis and anti hyperglycaemic activity of some novel selective glitazones as possible insulin sensitizers. RPS,AICTE  Government of India,  New Delhi. 2011 -2013  7.50 Lahs
                                                                                                                                 Total 25.56 Lakhs

Students fellowship

Students Research Fellowship (2008-2013)
Sl.
No.
Project Title Research Scholar Funding Agency Fellowship (In Lakhs)
1 Design, synthesis and antihyperglycemic evaluation of some novel peroxisome proliferation activates receptor
 (PPAR-y) agonist.
Mr.Pankaj Masih ICMR, Government of India,
New Delhi.2011-2012
5.12
2 Design, synthesis, evaluation and QSAR studies of novel carbazole / carbolic derivatives as antineoplastic agents. Mr.Ankur Gupta AICTE, Government of India,
New Delhi.2011-2012
6.8
3 Design, synthesis and evaluation of some novel dipeptidyl peptidase IV inhibitors as antidiabetic agents. Mrs.Rohini Diwedi UGC,
Government of India,
New Delhi.2011-2012
0.96
4 Isolation, screening and characterization of the fertility-regulating/fertility-enhancing phytoconstituents present in the traditional medicinal plants  of the Nilgiris, Derris brevipes VAR Coriaceae and Durio zebinthinus. Mr.Prince Francis CSIR, Government of India, New Delhi.
2009-2012
4.80
5 Structure activity relationship of bioactive compounds from medicinal plants. Mr.S.
Mahendran
UGC,
Government of India,
New Delhi.2009-2010
1.914
6 Design and development of controlled / sustained release formulations for certain newer drugs. Mr.K.
Krishnaraj
ICMR, Government of India, New Delhi.
2007-2009
5.04
7 Assessment of beneficial herb drug interaction –A Pharmacokinetic approach. Mr.Hemnath Elango JSS University, Mysore
2013-14
0.60
                                                                                                                                Total –  24.91

Programmes organized (QIP/SDP/Workshop/Seminar)

Sl. No. Title of the programme Sponsoring agency Date (s) Outcome
1 “Modern Techniques in Pharmaceutical Chemistry and Pharmaceutical Analysis”    AICTE ,
New Delhi          
14.3.2011 to 27.3.2011   Provided  platform for the newer and sophisticated  techniques in drug synthesis and quality assurance
2 Quality improvement Programme on Trends in Drug discovery and Drug Development AICTE ,
New Delhi           
 
09-03-2008 to 22-03-2008 Provided  platform for the newer methods for Drug discovery and Drug Development

Seminar to be Organized:

Computer Aided Drug Design-Development of new Molecules, Sponsored by JSS University, Mysore and ICMR, New Delhi on 16th and 17th of August, 2013.

Recent Scientific Publications:

  1. Synthesis and characterization of some novel fatty acid analogues: a preliminary investigation on their activity against human lung carcinoma cell line. Lipids in Health and Disease 2013;12(45):1-5.
  2. Synthesis and biological evaluation of some novel pyrazolopyrimidines incorporating benzothiazole ring system. Acta. Pharm. 2013, 63 (1), 19-30.
  3. Biological Activities of 2-Mercaptobenzothiazole Derivatives: A Review. Sci. Pharm., 80, 789-823, 2012:doi:10.3797/scipharm
  4. Synthetic strategies for the construction of δ–carbolines: A chemical ladder in search of Novel drugs. Current Organic synthesis, 2012, 9(3), 377-396.
  5. Targeting strategies for human immunodeficiency virus: A combinatorial approach. Mini Rev. Med. Chem., 2012, 12 (3),  236- 254.
  6. Synthesis and biological evaluation of some novel 2-mercaptobenzothiazoles carrying 2-pyrazoline.  J. Sc. Ind. Res., 2012, 71, 113-119.
  7. Synthesis of Benzothiazole substituted 4-arylidene-5-methyl-2,4-dihydro-3H-pyrazol-3-ones and 3-methyl-4,5-diaryl-4,5-dihydropyrazolo [3,4-c]pyrazoles as antimicrobial agents. Indian J. Heterocycl. Chem., 2012, 22, 47-52.
  8. Docking studies, synthesis, characterization and evaluation of their antioxidant and cytotoxic  activities of some novel isoxazole substituted 9-anilinoacridine derivatives. The scientific world Journal, 2012, 1-6.  doi:10.1100/165258.
  9. Design, synthesis and docking studies of a novel ciprofloxacin analogue as an antimicrobial  agent. Eur. J. Chem., 2012, 9(2), 980-987.
  10. Chiral HPLC method for the enantio selective analysis of rosiglitazone maleate in formulations. J Pharm.  Res., 2012, 5(1),79-81.
  11. Synthesis, and anticonvulsant screening of some novel 1,3,4-thiadiazole derivatives.   J. Pharm. Res., 2012, 5(1),58-60.
  12. New chiral normal phase HPLC method for the determination of pioglitazone enantiomers on its marketed formulation. J. Pharm. Res., 2012, 5(1),72-74.
  13. In vitro antioxidant activity of Solanum jasminoides Paxt extracts. J. Nat. Remed. 2012, 12 (2),114-117.
  14. A RP–HPLC method for simultaneous estimation of acelofenac, paracetamol & tizanidine HCl in Pharmaceutical formulation. 2012, J. Pharm. Res., 5(3), 1313 -1315.
  15. Synthesis, glucose uptake activity and structure-activity relationships ofsome novel glitazones incorporated with glycine, aromatic and alicyclic  amine moieties via two carbon acyl linker. Eur. J. Med. Chem., 2011, 46(3), 835-844.
  16. Synthesis and biological evaluation of some Schiff bases of [4-(amino)-5-phenyl-1, 4H-1,2,4-triazole-3-thiol. Pakistan J. Pharm. Sci., 2011, 24(2), 109-112.
  17. Synthesis and characterization of some novel quinoxaline-2,3dione derivatives: a preliminary investigation on their activity against human   epithelial carcinoma cell line. Lett. Drug Design  Discovery, 2011, 8 (4), 317-320.
  18. Synthesis and biological evaluation of some acetohydrazide incorporated 2- Mercaptobenzothiazoles. Indian drugs, 2011, 48(3), 9-15.
  19. New benzimidazolo Indane-1,3-dione derivatives : Synthesis and In-vitro screening against helminthes infections. Int. J. Drug Design  Discovery, 2011, 1(2), 506- 509.
  20. Development and validation of direct chiral separation of ibuprofen enantiomers of sustained    release dosage forms. J.  Pharm. Res. 2011, 4(6), 1617-1619.
  21. Design, synthesis and molecular docking studies of some novel ofloxacin analogues as  antimicrobial agents. Med. Chem. Res., 2011, Dol : 10.1007 / S 00044-011-9655-8.
  22. Isolation and evaluation of a polysaccharide from Prunus amygdalus as a carrier for transbuccosal delivery of Losartan potassium. International J.  Biol. Macromolecules, 2011, 48(5), 773-778.
  23. Poly(HEMA-Zidovudine) conjugate:A acromolecular pro-drug for improvement in the biopharmaceutical properties of the drug.  Drug Delivery, 2011, 18(4) 272-280.
  24. Microwave assisted synthesis of some novel pyrazole substituted  benzimidazoles and        evaluation of their biological activities. Indian J. Chem., 2011, 50B, 1794-1799.

Patents Filed/Granted

Sl. No Title of the Patent File No & Date Status
  1. Composition of a copper-Quercetin nano complex for treating human Papilloma virus infected cervical 761/CHEM/2013 Filed*

*** Collaboration with the Department of Pharmaceutics

Research Papers Presented 

Sl. No. Title of presentation Presenting Author Name of the Seminar/Conferences/
Workshops
Organised by and date (s)

1

“CADD-Development of New Molecule”
as a Resource person
Dr. Md. Afzal Azam Patient Safety and CADD-Molecular Modelling in Drug Design Seven Hills College of Pharmacy, Tirupati A.P.April 5, April 2013.

2

Synthesis and biological evaluation of some 1,3,4- oxadiazole  in corporate 2- mercaptobenzothiazoles.  Dr. Md. Afzal Azam National conference 
on evolving Paradigms in molecular  Pharmacology and drug design.
Ultra college of
Pharmacy, Madurai, Sponsored by CSIR and ICMR, New Delhi. Dated  17-18, March  2011.

3

Design, synthesis and molecular docking studies of some novel  ofloxacin analogues as antimicrobial agents S. Jubie   71st International  congress FIP, Hyderabad, India, Dated 3-8 September 2011.

4

Synthesis and characterization of 1{(diethylcarbamoyl)methyl}-3-(5-aryl-1,3,4-thiadiazol-2-yl) urea derivatives as anticancer agents. Dr. B. Gowramma 71st   International  congress FIP, Hyderabad, India, Date 3-8 September 2011.

5

Synthesis And anticonvulsant activity of some novel 1-(5-aryl-1,3,4-thiadiazol-2-yl) urea derivatives. S. Gomathy 71st  International  congress. FIP, Hyderabad, India, Dated 3-8 September 2011.

6

Synthesis & characterization of 1[(diethyl carbamoyl) methyl] -3-(5-aryl 1,3,4-thiadiazole-2-yl) urea derivatives as antimicrobial agents.
Abstract No.DDD 045
Dr. B. Gowramma Indo-US Symposium on Medicinal Chemistry & drug discovery. JSS University, Mysore on 21st – 23rd April 2011.

7

Synthesis & antimicrobial activity of some hexahydro cyclopenta pyrazoles / oxazole.
Abstract No. DDD 022
S. Gomathy Indo-US Symposium on Medicinal Chemistry & drug discovery. JSS University, Mysore on 21st – 23rd April 2011.

8

Synthesis and biological evaluation  of some novel 2-pyrazolines incorporated 2-mercaptobenzothiazoles.
Abstract No. DDD  035
Dr. Md. Afzal Azam Indo-US Symposium on Medicinal Chemistry & drug discovery. JSS University, Mysore on 21st – 23rd April 2011.

9

Microwave induced synthesis and antimicrobial activity of some novel isoxazole substituted 9-anilino acridine derivatives.
Abstract No. DDD  042
R. Kalirajan Indo-US Symposium on Medicinal Chemistry & drug discovery. JSS University, Mysore on 21st – 23rd April 2011.

10

Design, synthesis, molecular docking studies of novel ofloxacin analogues as cytotoxic agents.
Abstract No. DDD 37
S. Jubie Indo-US Symposium on Medicinal Chemistry & drug discovery. JSS University, Mysore on 21st – 23rd April 2011.

11

The symbiotic Collaboration between Pharmaceutical Industry and Academia in the Eradication of Diseases.
Abstract No. K 24.
Dr. S. Sankar, 63rd Indian Pharmaceutical Congress. IPCA,16th  - 18th
December 2011
Bengaluaru.

12

Microwave assisted synthesis, characterization and evaluation of their larvicidal activities of some novel chalcone substituted acridine derivatives.
Abstract. No. B 364
R. Kalirajan 63rd Indian Pharmaceutical Congress. IPCA,16th  - 18th
December 2011
Bengaluaru.

13

Microwave induced synthesis and antioxidant activities of some novel isoxazole substituted 9-anilino acridine derivatives.
Abstract. No. B 361.
R. Kalirajan 63rd Indian Pharmaceutical Congress. IPCA,16th  - 18th
December 2011
Bengaluaru.

14

Design, Molecular docking studies and synthesis of some novel fatty acid  analogues as antimicrobial agents.
Abstract. No. B 282.
S. Jubie 63rd Indian Pharmaceutical Congress. IPCA,16th  - 18th
December 2011
Bengaluaru.

15

Synthesis, anticonvulsant activity of some novel 1,3,4-thiadiazole derivatives.
Abstract. No. B 217.
Dr. B. Gowramma 63rd  Indian Pharmaceutical Congress. IPCA,16th  - 18th
December 2011
Bengaluaru.

16

Synthesis & antidepressant activity of some novel 1,5-benzothiazipines derivatives.
Abstract. No. B 82.
S. Gomathy 63rd  Indian Pharmaceutical Congress. IPCA,16th  - 18th
December 2011
Bengaluaru.

Placement detail 2013: Post graduate students are engaged in various organizations

2013 Pass out

  1. Mr. Pankaj Niranjan—MicroLabs Limited, Bangalore
  2. Mr. B. Prasanth- Novartis Health Care Pvt. Ltd., Hyderabad
  3. Mr. Subhankar Joshi-Himalaya herbal Healthcare, Bangalore
  4. Mr. Sagun Sharma-Biocon, Bangalore
  5. Mr. Gyanendra Singh-Aurobindo Pharma Ltd., Hyderabad
  6. Mr. Gaurav Singh-Wochhardt  Limited